In addition, tamoxifen-sensitive and NG2 gene locus-dependent gene recombination could be detected in a small, but persistent population of cortical NeuN + neurons starting from the second postnatal week.

However, in other brain regions, such as olfactory bulb, brain stem, and cerebellum, all of the NG2 glia was restricted to the OL lineage. Interestingly, when Cre activity was induced at embryonic stages, a significant number of reporter + astrocytes could be detected in the gray matter after birth.

Fast and easy I recently processed over 500 catalog images with the Wacom Intuos 5 and found I could save more than 30 of the time it took with the earlier Intuos tablet - so, the new tablet bought itself in about 2 days. in NKX2.2 null mice, although their subsequent differentiation into OLs is prevented (Qi et al., 2001). Wacom now has a Radial menu, which gives you access to Brushes, Pen tools and even Photoshop actions with a one-button access. Results from this novel mouse line demonstrate that at different developmental stages of the brain, NG2 + cells either stayed as NG2 glia or differentiated into OLs during the whole life span. Volume 69, Issue 5, 10 March 2011, Pages 918-929. ponent variables into OLS regression analysis in order to remedy misspecification and the. To minimize these restrictions and to more faithfully mimic the endogenous NG2 expression in vivo, we generated a mouse line in which the open reading frame of the tamoxifen-inducible form of the Cre DNA recombinase (CreERT2) was inserted into the NG2 locus by homologous recombination. However, the differentiation potential of NG2 glia remained controversial, largely attributable to shortcomings of transgenic mouse models used for fate mapping. In the parenchyma of the central nervous system, NG2-expressing (NG2 +) cells have been identified as a novel type of glia with a strong potential to generate oligodendrocytes (OLs) in the developing white matter. NG2 (nerve/glia antigen-2) is a type I transmembrane glycoprotein and also known as chondroitin sulfate proteoglycan 4.

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